PUBLICATIONS

2019 - Present

  1. Jones, S.; Transue, W. J.; Meier, K. K.; Kelemen, B.; Solomon, E. “Kinetic analysis of amino acid radicals formed in H2O2-driven Cu(I) LPMO reoxidation implicates dominant homolytic reactivity.” Proc. Natl. Acad. Sci. USA. 2020, 117, 11916-11922.
  2. Paulino, V.; Mukhopadhyay, A.; Tsironi, I.; Liu, K.; Husainy, D.; Liu, C.; Meier, K.*; Olivier, J.-H.* “Molecular Engineering of Water-Soluble Oligomers to Elucidate Radical pi-Anion Interactions in n-Doped Nanoscale Objects.” J. Phys. Chem. C. 2021, 125, 19, 10526-10538.
  3. El Metwally A. E., Goodarzi, F., Meier, K. K., Zahran, E. M., Rayat, S., Kegnæs, S., Knecht, M. R., Bachas, L. G. “Cu2S@Bi2S3 Double-Shelled Hollow Cages as a Nanocatalyst with Substantial Activity in Peroxymonosulfate Activation for Atrazine Degradation” ACS Applied Nano Materials. 2021, 4, 11, 12222-12234.
  4. Lobato, A.G., Ortiz-Vega. N., Zhu, Y., Neupane, D., Meier. K., Zhai. R.G. “Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington’s disease.” Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. 2024, 1870, 1, 166928. (Published online: doi.org/10.1016/j.bbadis.2023.166928)
  5. Lim, H.; Brueggemeyer, M.; Transue, W.; Meier, K.; Jones, S.; Kroll, T.; Sokaras, D.; Kelemen, B.;Hedman, B.; Hodgson, K.; Solomon, E. “Kβ X-ray Emission Spectroscopy of Cu(I)-Lytic Polysaccharide Monooxygenase: Direct Observation of the Frontier Molecular Orbital for H2O2 Activation" J. Am. Chem. Soc. 2023, 145, 29, 16015-16025.

Before U Miami

  1. Appel, M. J.*; Meier, K. K.*; Lafrance-Vanasse, J.; Lim, H.; Tsai, C.-L.; Tainer, J. A.; Solomon, E. I.; Bertozzi, C. R. “The formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation” (*co-first authors) Proc. Natl. Acad. Sci. 2019, 116, 5370-5375. (Highlighted in: Schilter, D. Nature Reviews Chemistry 2019, 3, 203.)
  2. Meier, K.; Jones, S.; Kaper, T.; Hansson, H.; Koetsier, M.; Sarkehabadi, S.; Solomon, E.; Sandgren, M.; Keleman, B. “Oxygen activation by Cu LPMOs in recalcitrant carbohydrate polysaccharide conversion to monomer sugars.” Chem. Rev. 2018, 118, 2593-2635.
  3. Hansson, H.; Karkehabadi, S.; Mikkelsen, N.; Douglas, N.; Kim, S.; Lam, A.; Kaper, T.; Kelemen, B.; Meier, K. K.; Jones, S. M.; Solomon, E. I.; Sandgren, M. “A lytic polysaccharide monooxygenase from Hypocrea jecorina with a structurally defined linker sequence.” Biol. Chem. 2017, 292, 19099-19109.
  4. Meier, K. K.; Rogers, M.; Kovaleva, E. G.; Lipscomb, J. D.; Münck, E. Bominaar, E. “Enzyme Substrate Complex of the H200C Variant of Homoprotcatechuate 2,3-Dioxygenase: Mossbauer and Computational Studies.” Inorganic Chemistry. 2016, 55, 5862-5870.
  5. Meier, K. K.; Rogers, M.; Kovaleva, E. G.; Bominaar, E.; Lipscomb, J. D.; Münck, E. “A Long-Lived Fe(III)-(Hydroperoxo) Intermediate in the Active H200C Variant of Homoprotocatechuate 2,3-Dioxygenase: Characterization by Mossbauer, Electron Paramagnetic Resonance, and Density Functional Theory Methods.” Inorganic Chemistry. 2015, 54, 10269-10280.
  6. Prakash, J.; Rohde, G. T.; Meier, K. K.; Munck, E.; Que Jr., L. “Upside Down! Crystallographic and Spectroscopic Characterization of an [FeIV(Osyn)(TMC)]2+” Inorganic Chemistry. 2015, 54, 11055-11057.
  7. Serrano-Plana, J.; Oloo, W. N.; Acosta-Rueda, L.; Meier, K. K.; Verdejo, B.; Garcia-Espana, E.; Basallote, M. G.; Munck, E.; Que, Jr., L.; Company, A.; Costas, M. “Trapping a Highly Reactive Nonheme Iron Intermediate That Oxygenates Strong C-H Bonds with Stereoretention.” Am. Chem. Soc. 2015, 137, 15833-15842.
  8. Prakash, J.; Rohde, G. T.; Meier, K. K.; Jasniewski, A. J.; Van Heuvelen, K. M.; Munck, E.; Que, Jr., L. “Spectroscopic identification of an Fe(III) center, not Fe(IV), in the crystalline Sc-O-Fe adduct derived from [Fe(IV)(O)(TMC)]2+. Am. Chem. Soc. 2015, 137, 3478-3481.
  9. Biswas, A. N.; Puri, M. Meier, K. K.; Oloo, W. N.; Rohde, G. T.; Munck, E.; Que, Jr., L. “Modeling TauD-J: a high-spin nonheme oxoiron(IV) complex with high reactivity toward C-H bonds.” Am. Chem. Soc. 2015, 137, 2428-2431.
  10. Makris, T. M.; Vu, V. V.; Meier, K. K.; Komor, A. J.; Rivard, B. S.; Munck, E.; Que, Jr., L.; Lipscomb, J. D. “An Unusual Peroxo Intermediate of the Arylamine Oxygenase of the Chloramphenicol Biosynthetic Pathway.” J. Am. Chem. Soc. 2015, 136, 1608-1617.
  11. *Liu, J.; Meier, K.; Tian, S.; Zhang, J.; Guo, H.; Schulz, C. E.; Robinson, H.; Nilges, M. J.; Munck, E.; Lu, Y. “Redesigning an Electron Transfer Protein into a Mononuclear Non-heme Iron Enzyme: Preparation and Study of Fe(II)-M121E Azurin.” Am. Chem. Soc. 2014, 136, 12337-12344. *Co-first authors
  12. Chiang, C.-W.; Kleespies, S. T.; Stout, H. D.; Meier, K. K.; Li, P.-Y.; Bominaar, E. L.; Que, Jr., L.; Munck, E.; Lee, W.-Z. “Characterization of a Paramagnetic Mononuclear Nonheme Iron-Superoxo Complex.” Am. Chem. Soc. 2014, 136, 10846-10849.
  13. England, J.; Bigelow, J.O.; Van Heuvelen, K.M.; Farquhar, E.R.; Martinho, M.; Meier, K.K.; Frisch, J.R.; Munck, E.; Que, Jr., L. “An Ultra-Stable Oxoiron(IV) Complex and Its Blue Conjugate Base.” Sci. 2014, 5, 1204-1215.
  14. Oloo, W.N.; Meier, K.K., Munck, E., Que Jr., L. “Identification of a low-spin acylperoxoiron(III) intermediate in bio-inspired non-heme iron-catalysed oxidations.” Nature Commun. 2014, 5, 3046.
  15. Li, F.; Van Heuvelen, K.M.; Meier, K.K.; England, J.; Münck, E.; Que, Jr., L. “Sc3+ triggered oxoiron(IV) formation from O2 and its nonheme iron(II) precursor via a Sc3+-peroxo-Fe3+” J. Am. Chem. Soc. 2013, 135, 10198-10201.
  16. Banerjee, R.; Meier, K.; Münck, E.; Lipscomb, J.D. “Intermediate P* from Soluble Methane Monooxygenase Contains a Diferrous Cluster.” Biochemistry. 2013, 52, 4331-4342.
  17. Mbughuni, M.M.; Meier, K.K.; Münck, E.; Lipscomb, J.D. “Substrate-Mediated Oxygen Activation by Homoprotocatechuate 2,3-Dioxygenase: Intermediates Formed by a Tyrosine 257 Variant.”  Biochemistry.  2012, 51, 8743-8754.
  18. Cranswick, M.A.; Meier, K.K.; Shan, X.; Stubna, A.; Kaizer, J.; Mehn, M.P.; Münck, E.; Que, Jr., L. “Protonation of a Peroxodiiron(III) Complex and Conversion to a Diiron (III/IV) Intermediate: Implications to Proton-assisted O-O Bond Cleavage in Nonheme Diiron Enzymes.”  Inorganic Chemistry. 2012, 5, 10417-10426.
  19. Van Heuvelen, K.M.; Fiedler, A.T.; DeHont, R.; Shan, X.; Meier, K.K.; Bominaar, E.; Münck, E.; Que, Jr. L. “One-electron oxidation of an oxoiron(IV) complex to form an  [O=FeV=NR]+” Proc. Ntl. Acad. Sci. 2012, 109, 11933-11938.
  20. Mbughuni, M.M.; Chakrabarti, M.; Hayden, J.A.; Meier, K.K.; Dalluge, J.J.; Hendrich, M.P.; Münck, E.; Lipscomb, J.D. “Oxy-intermediates of homoprotocatechuate 2,3-dioxygenase: facile electron transfer between substrates.”  Biochemistry. 2011, 50, 10262-10274.
  21. Li, F.; Meier, K.K.; Cranswick, M.A.; Chakrabarti, M.; Van Heuvelen, K.M.; Münck, E.; Que, Jr., L. “Characterization of a High-Spin Non-Heme FeIII-OOH Intermediate and Its Quantitative Conversion to an FeIV=O Complex.” Am. Chem. Soc. 2011, 133, 7256-7259.
  22. Walsh, J.D.; Meier, K.; Ishima, R.; Gronenborn, A.M. “NMR Studies on Domain Diffusion and Alignment in Modular GB1 Repeats.” Biophysical Journal. 2010, 99, 2636-2646.